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The Biden-Harris Administration has taken important and crucial steps to provide relief to the most vulnerable populations abroad, such as through the American Rescue Plan’s supplemental funding for the international response; contributions to Gavi, the Vaccine Alliance; and commitments to provide 500 million vaccine doses and donate another 80 million excess doses to low- and middle-income countries. But vaccine donations alone are insufficient; they must be complemented by clear plans for and investments in the efficient and rapid delivery of doses, with careful attention to areas not reached by national governments.